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Vermaat authored
In case of an alternative start codon, the variant CDS was not translated to a protein starting with M. This caused the protein description machinery to conclude a variant affecting the start codon, hence reporting `p.?`. We fix this by always translating the start codon to M (except when the variant actually affects it). Example: `NM_024426.4:c.1107A>G` (a synomymous mutation) should yield `NM_024426.4(WT1_i001):p.(=)`, not `p.?`. The start codon for that protein is `CTG`.
Vermaat authoredIn case of an alternative start codon, the variant CDS was not translated to a protein starting with M. This caused the protein description machinery to conclude a variant affecting the start codon, hence reporting `p.?`. We fix this by always translating the start codon to M (except when the variant actually affects it). Example: `NM_024426.4:c.1107A>G` (a synomymous mutation) should yield `NM_024426.4(WT1_i001):p.(=)`, not `p.?`. The start codon for that protein is `CTG`.