- Sep 24, 2015
- Sep 23, 2015
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Vermaat authored
Show diff for variant protein from non-reference start codon
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Vermaat authored
The alternative variant protein sequence translated from a non-reference start codon (created by the variant), was not color-diffed as normal variant protein sequences are. In the process we also rename the `oldprotein` and `newprotein` fields in the output object to `oldProtein` and `newProtein` to be more consistent with other field names.
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Vermaat authored
Translate alternative start to M, also in variant
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Vermaat authored
In the case of an alternative start codon (in the reference CDS), protein changes were not visualised. This is fixed and a WALTSTART warning is also issued. Also, if a new non-reference start codon is created by the variant, visualise this as such.
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Vermaat authored
In case of an alternative start codon, the variant CDS was not translated to a protein starting with M. This caused the protein description machinery to conclude a variant affecting the start codon, hence reporting `p.?`. We fix this by always translating the start codon to M (except when the variant actually affects it). Example: `NM_024426.4:c.1107A>G` (a synomymous mutation) should yield `NM_024426.4(WT1_i001):p.(=)`, not `p.?`. The start codon for that protein is `CTG`.
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- Sep 22, 2015
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Vermaat authored
Disable Travis-CI notifications on Slack
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- Sep 21, 2015
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Vermaat authored
We see the Travis-CI status in GitHub pull requests anyway.
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- Sep 18, 2015
- Sep 11, 2015
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Vermaat authored
Using the Werkzeug reloader is configurable
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Vermaat authored
The Werkzeug reloader is disabled by default due to a bug with using it in combination with `python -m mutalyzer.entrypoints.website`. https://github.com/mitsuhiko/werkzeug/issues/461#issuecomment-139369694
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- Sep 07, 2015
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Vermaat authored
Fix service location in SOAP WSDL document
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Vermaat authored
By default, the first request to the SOAP service will trigger a build of the WSDL document, using the context (service location) from that request. For example, if the first request is on `http://localhost/` and subsequent requests are on `https://mutalyzer.nl/services/`, they will not have a valid WSDL document. This is actually what we do on our production infrastructure, where the service is tested (on localhost) after it has been started. The fix is to force a build of the WSDL document and specifying the location to use. http://spyne.io/docs/2.10/reference/server.html#spyne.server.wsgi.WsgiApplication
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- Aug 28, 2015
- Aug 11, 2015
- Aug 10, 2015
- Aug 06, 2015
- Aug 04, 2015
- Jul 21, 2015
- Jul 20, 2015
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Vermaat authored
For transcripts without any UTR and CDS entries in the NCBI Mapview file (seems to happen for predicted genes), we generate one exon spanning the entire transcript.
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- Jul 16, 2015
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Vermaat authored
Fix typo in docs
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