• Hoogenboom, Jerry's avatar
    Improved sequence aligment (variant calling) quality · e1bd3e41
    Hoogenboom, Jerry authored
    FDSTools would sometimes produce suboptimal alignments. Most notably, it
    it would produce multiple smaller insertions/deletions when the
    difference between two sequences could be described by one larger
    insertion/deletion in combination with a base substitution. The latter
    description is often more biologically sound and also usually results in
    a shorter allele name.
    
    * Fixed a bug that sometimes caused FDSTools to choose an incorrect path
      through the alignment matrix, producing a suboptimal alignment.
    * Tweaked the alignment parameters to produce more meaningful results.
    e1bd3e41
lib.py 66 KB