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  \vspace{-0.5cm}

  \begin{center}

    \fbox{

      \begin{picture}(300, 60)(0, 0)

        \put(0, 30){\line(1, 0){300}}  % Genomic sequence.

        \linethickness{4pt}

        \put(50, 30){\line(1, 0){30}}  % Non-coding parts of the exons.

        \put(220, 30){\line(1, 0){10}}

        \linethickness{12pt}

        \put(80, 30){\line(1, 0){20}}  % Coding parts of the exons.

        \put(150, 30){\line(1, 0){20}}

        \put(200, 30){\line(1, 0){20}}

        \linethickness{0.5pt}

        \put(15, 50){\scriptsize{Transcription start}}

        \put(50, 45){\vector(0, -1){10}}

        \put(200, 50){\scriptsize{Transcription end}}

        \put(230, 45){\vector(0, -1){10}}

        \put(70, 0){\scriptsize{CDS start}}

        \put(80, 10){\vector(0, 1){10}}

        \put(205, 0){\scriptsize{CDS stop}}

        \put(220, 10){\vector(0, 1){10}}

        \put(0, 0){\scriptsize{Genomic end}}

        \put(0, 10){\vector(0, 1){10}}

        \put(252, 0){\scriptsize{Genomic start}}

        \put(300, 10){\vector(0, 1){10}}

        \put(95, 50){\color{yellow}\scriptsize{Variant A}\color{white}}

        \put(115, 45){\color{yellow}\vector(0, -1){10}\color{white}}

        \put(140, 50){\color{yellow}\scriptsize{Variant B}\color{white}}

        \put(160, 45){\color{yellow}\vector(0, -1){10}\color{white}}

      \end{picture}

    }

  \end{center}

  \bigskip

}

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  \put(0, 10){\line(1, 0){300}}     % Genomic sequence.

  \put(0, 14){{\scriptsize reference}}

  \put(110, 20){\vector(1, 0){30}}  % Paired read.

  \put(210, 20){\vector(-1, 0){30}}

  \put(200, 17.5){{\bf$\times$}}

  \put(50, 30){\vector(1, 0){30}}   % Paired read.

  \put(60, 27.5){{\bf$\times$}}

  \put(140, 30){\vector(-1, 0){30}}

  \put(130, 27.5){{\bf$\times$}}

  \put(180, 30){\vector(1, 0){30}}  % Paired read.

  \put(270, 30){\vector(-1, 0){30}}

  \put(250, 27.5){{\bf$\times$}}

  \put(260, 27.5){{\bf$\times$}}

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