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This repo contains source code for the paper "Controlling bias and inflation in epigenome- and transcriptomewide association studies using the empirical null distribution" by Maarten van Iterson, Erik W. van Zwet and Bastiaan T. Heijmans.
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Leiden450K contains a couple of functions for preprocessing of Illumina Human 450K array data, such as reading idat files in parallel, filtering probes and normalization.
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Code used to prepare disease data in survival format, calculate LRC score, data QC and preparation, and data analyses.
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