vt.wdl

version 1.0

# Copyright (c) 2020 Sequencing Analysis Support Core - Leiden University Medical Center
#
# Permission is hereby granted, free of charge, to any person obtaining a copy
# of this software and associated documentation files (the "Software"), to deal
# in the Software without restriction, including without limitation the rights
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# copies of the Software, and to permit persons to whom the Software is
# furnished to do so, subject to the following conditions:

# The above copyright notice and this permission notice shall be included in all
# copies or substantial portions of the Software.

# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
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# SOFTWARE.

task Normalize {
    input {
        File inputVCF
        File inputVCFIndex
        File referenceFasta
        File referenceFastaFai
        Boolean ignoreMaskedRef = false
        String outputPath = "./vt/normalized_decomposed.vcf"
        String dockerImage = "quay.io/biocontainers/vt:0.57721--hdf88d34_2"
        String memory = "4G"
        Int timeMinutes = 30
    }

    command {
        set -eo pipefail
        mkdir -p "$(dirname ~{outputPath})"
        vt normalize ~{inputVCF} \
        -r ~{referenceFasta} \
        ~{true="-m " false="" ignoreMaskedRef} \
        | vt decompose -s - -o ~{outputPath}
    }

    output {
        File outputVcf = outputPath
    }

    runtime {
        memory: memory
        time_minutes: timeMinutes
        docker: dockerImage
    }

    parameter_meta {
        # inputs
        inputVCF: {description: "The VCF file to process.", category: "required"}
        inputVCFIndex: {description: "The index of the VCF file to be processed.", category: "required"}
        outputPath: {description: "The location the output VCF file should be written.", category: "common"}
        referenceFasta: {description: "The reference fasta file which was also used for mapping.", category: "required"}
        referenceFastaFai: {description: "The index for the reference fasta file.", category: "required"}
        ignoreMaskedRef: {description: "Warns but does not exit when REF is inconsistent with masked reference sequence for non SNPs", category: "advanced"}
        memory: {description: "The memory required to run the programs", category: "advanced"}
        timeMinutes: {description: "The maximum amount of time the job will run in minutes.", category: "advanced"}
        dockerImage: {description: "The docker image used for this task. Changing this may result in errors which the developers may choose not to address.", category: "advanced"}
    }
}