diff --git a/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/Makefile b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/Makefile
new file mode 120000
index 0000000000000000000000000000000000000000..67bbf579c8e015b89a498cc73261f6956a6e1de8
--- /dev/null
+++ b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/Makefile
@@ -0,0 +1 @@
+/local/projects/poster/trunk/Makefile
\ No newline at end of file
diff --git a/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/beamerthemelumc.sty b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/beamerthemelumc.sty
new file mode 120000
index 0000000000000000000000000000000000000000..c4ebe290a885f9cc0b1d4c6e921bcdff05864d9e
--- /dev/null
+++ b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/beamerthemelumc.sty
@@ -0,0 +1 @@
+/local/projects/poster/trunk/beamerthemelumc.sty
\ No newline at end of file
diff --git a/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/gen2phen_logo.eps b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/gen2phen_logo.eps
new file mode 120000
index 0000000000000000000000000000000000000000..c6bbd6d415aad4279a2970bef42f50c7e8def74b
--- /dev/null
+++ b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/gen2phen_logo.eps
@@ -0,0 +1 @@
+/local/projects/poster/trunk/gen2phen_logo.eps
\ No newline at end of file
diff --git a/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/lgtc_logo.eps b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/lgtc_logo.eps
new file mode 120000
index 0000000000000000000000000000000000000000..0aa852be38458a27f4cf58c47b4b3859b684bd3d
--- /dev/null
+++ b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/lgtc_logo.eps
@@ -0,0 +1 @@
+/local/projects/poster/trunk/lgtc_logo.eps
\ No newline at end of file
diff --git a/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/lumc_logo.eps b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/lumc_logo.eps
new file mode 120000
index 0000000000000000000000000000000000000000..218d986e99adaf98d688e482751bc059a7cd75f7
--- /dev/null
+++ b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/lumc_logo.eps
@@ -0,0 +1 @@
+/local/projects/poster/trunk/lumc_logo.eps
\ No newline at end of file
diff --git a/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/mutalyzerNameCheck.eps b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/mutalyzerNameCheck.eps
new file mode 120000
index 0000000000000000000000000000000000000000..a140e29c0ae3187b6a0c2a6316dfefe6b4f5e4ca
--- /dev/null
+++ b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/mutalyzerNameCheck.eps
@@ -0,0 +1 @@
+/local/doc/presentationpics/mutalyzerNameCheck.eps
\ No newline at end of file
diff --git a/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/mutalyzerPositionConvert.eps b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/mutalyzerPositionConvert.eps
new file mode 120000
index 0000000000000000000000000000000000000000..7e29fca25502269b13ddd82ecfbd1514cb639f53
--- /dev/null
+++ b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/mutalyzerPositionConvert.eps
@@ -0,0 +1 @@
+/local/doc/presentationpics/mutalyzerPositionConvert.eps
\ No newline at end of file
diff --git a/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/nbic_logo.eps b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/nbic_logo.eps
new file mode 120000
index 0000000000000000000000000000000000000000..47de9bc5831b3d67f476e694555bece4dc451fa0
--- /dev/null
+++ b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/nbic_logo.eps
@@ -0,0 +1 @@
+/local/projects/poster/trunk/nbic_logo.eps
\ No newline at end of file
diff --git a/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/positionpicture.tex b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/positionpicture.tex
new file mode 100644
index 0000000000000000000000000000000000000000..d9d593c2a0345f8c4c75e07e10b3f6ddd6df9420
--- /dev/null
+++ b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/positionpicture.tex
@@ -0,0 +1,38 @@
+\vspace{-0.5cm}
+\begin{center}
+ \colorbox{white}{
+ \begin{picture}(300, 60)(0, 0)
+ \put(0, 30){\line(1, 0){300}} % Genomic sequence.
+ \linethickness{4pt}
+ \put(50, 30){\line(1, 0){30}} % Non-coding parts of the exons.
+ \put(220, 30){\line(1, 0){10}}
+ \linethickness{12pt}
+ \put(80, 30){\line(1, 0){20}} % Coding parts of the exons.
+ \put(150, 30){\line(1, 0){20}}
+ \put(200, 30){\line(1, 0){20}}
+
+ \linethickness{0.5pt}
+ \put(20, 50){\scriptsize{Transcription start}}
+ \put(50, 45){\vector(0, -1){10}}
+ \put(200, 50){\scriptsize{Transcription end}}
+ \put(230, 45){\vector(0, -1){10}}
+
+ \put(70, 0){\scriptsize{CDS start}}
+ \put(80, 10){\vector(0, 1){10}}
+ \put(210, 0){\scriptsize{CDS stop}}
+ \put(220, 10){\vector(0, 1){10}}
+
+ \put(0, 0){\scriptsize{Genomic end}}
+ \put(0, 10){\vector(0, 1){10}}
+ \put(270, 0){\scriptsize{Genomic start}}
+ \put(300, 10){\vector(0, 1){10}}
+
+ \put(95, 50){\color{red}\scriptsize{Variant A}\color{black}}
+ \put(115, 45){\color{red}\vector(0, -1){10}\color{black}}
+
+ \put(140, 50){\color{red}\scriptsize{Variant B}\color{black}}
+ \put(160, 45){\color{red}\vector(0, -1){10}\color{black}}
+ \end{picture}
+ }
+\end{center}
+\bigskip
diff --git a/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/poster.bbl b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/poster.bbl
new file mode 100644
index 0000000000000000000000000000000000000000..6a122bbe4e652a08f23be6f40d864eb0665d4ded
--- /dev/null
+++ b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/poster.bbl
@@ -0,0 +1,17 @@
+\begin{thebibliography}{1}
+
+\bibitem{HGVS}
+{Human Genome Variation Society}.
+\newblock \begin{small}\texttt{http://www.hgvs.org/}\end{small}.
+
+\bibitem{LOVD}
+I.~Fokkema, J.~{den}~Dunnen, and P.~Taschner, ``{LOVD}: easy creation of a
+ locus-specific sequence variation database using an ``{LSDB-in-a-Box}''
+ approach.,'' {\em Human Mutation}, vol.~26, no.~2, pp.~63--68, 2005.
+
+\bibitem{LRG}
+R.~e.~a. Dalgleish, ``Locus reference genomic,'' {\em Genome Med}, vol.~2,
+ p.~24, 2010.
+\newblock See also {\small\texttt{http://www.lrg-sequence.org/}}.
+
+\end{thebibliography}
diff --git a/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/poster.tex b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/poster.tex
new file mode 100644
index 0000000000000000000000000000000000000000..d149e5ff99f70faed5a0c4652b61828f1989678a
--- /dev/null
+++ b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/poster.tex
@@ -0,0 +1,123 @@
+\documentclass[final, slidestop]{beamer}
+
+\title{Mutalyzer 2.0: Improved sequence variant descriptions from next
+ generation sequencing data and gene variant databases}
+\author{Jeroen F. J. Laros, Martijn Vermaat, Gerben Stouten, \\
+ Johan T. den Dunnen, Peter E. M. Taschner}
+\institute{Center for Human and Clinical Genetics, Leiden University Medical
+ Center, Leiden, The Netherlands}
+\providecommand{\centerLogo}{
+ \includegraphics[height = 3cm]{gen2phen_logo}
+}
+\providecommand{\rightLogo}{
+ \includegraphics[height = 3cm]{nbic_logo}
+}
+\providecommand{\colOneWidth}{0.48}
+\providecommand{\colTwoWidth}{0.48}
+
+\usetheme{lumc}
+
+\begin{document}
+
+\begin{frame}{}
+ \begin{myPoster}
+ \colorBlock{Background}{Introduction}{1}{
+ Unambiguous and correct sequence variant descriptions are of utmost
+ importance for DNA diagnostics. The free Mutalyzer sequence variation
+ nomenclature checker
+ (\color{red}\bt{http://www.mutalyzer.nl/}\color{LUMCBlue}) names variants
+ following the Human Genome Variation Society (HGVS) sequence variant
+ nomenclature recommendations~\cite{HGVS}.
+
+ \begin{figure}
+ \vspace{2cm}
+ \setlength{\unitlength}{0.12cm}
+ \input{positionpicture}
+ \caption{Key positions in HGVS numbering scheme.}
+ \label{fig:positions}
+ \end{figure}
+
+ \begin{table}
+ \caption{Positions from Fig.~\ref{fig:positions} in HGVS genomic (g.),
+ non-coding (n.) and coding DNA (c.) notations.}
+ \colorbox{white}{
+ \begin{tabular}{l|r|r|r}
+ Key position & \bt{g.} & \bt{n.} & \bt{c.} \\
+ \hline
+ Genomic end & \bt{300} & \bt{1-u50} & \bt{-30-u50} \\
+ Transcription start & \bt{250} & \bt{1} & \bt{-30} \\
+ CDS start & \bt{220} & \bt{30} & \bt{1} \\
+ CDS stop & \bt{80} & \bt{90} & \bt{60} \\
+ Transcription end & \bt{70} & \bt{100} & \bt{*10} \\
+ Genomic start & \bt{1} & \bt{100+d70} & \bt{*10+d70} \\
+ \end{tabular}
+ }
+ \end{table}
+ }
+ \colorBlock{WhiteBg}{Conclusions}{1}{
+ Variants at intergenic, exonic, intronic, CDS and UTR positions can be
+ easily distinguished based on their gene-centered HGVS descriptions.
+ Mutalyzer facilitates batch-wise conversion from dbSNP rsIDs or
+ chromosomal position numbering of next generation sequencing data to
+ transcript position numbering, as well as sequence variant checking of
+ locus-specific sequence variant databases (LSDBs)~\cite{LOVD}.
+ }
+ \colorBlock{SalmonBg}{Position Conversion}{1}{
+ The position converter in batch mode is especially suited for NGS
+ applications. It can handle large numbers of genomic variant descriptions
+ and converts them to transcript-oriented positions. Following a semantic
+ check with the batch Name Checker, variant descriptions can be used for
+ annotation. CDS, exon and intron positions can be easily distinguished
+ from the HGVS descriptions and used to query LSDBs.
+
+ \begin{figure}
+ {
+ \includegraphics[width = 0.85\textwidth, height = 18cm]{mutalyzerPositionConvert}
+ }
+ \caption{Mutalyzer 2.0 Position Converter.}
+ \label{figure:positionconvert}
+ \end{figure}
+ }
+ \colorBlock{YellowBg}{Acknowledgements}{1}{
+ {\small
+ Funded by the European Community's Seventh Framework Programme
+ (FP7/2007-2013) under grant agreement no. 200754 - the GEN2PHEN project.
+ }
+
+ }
+ \nextColumn
+ \colorBlock{BlueBg}{Name Checking}{1}{
+ \begin{figure}
+ {
+ \includegraphics[width = 0.95\textwidth, height = 57cm]{mutalyzerNameCheck}
+ }
+ \caption{Mutalyzer 2.0 Name Checker using a LRG reference
+ sequence~\cite{LRG}}
+ \label{figure:namecheck}
+ \end{figure}
+ }
+ \colorBlock{GreenBg}{Interfaces}{1}{
+
+ \begin{tabular}{l@{\ \ --\ \ }p{25cm}}
+ Name Checker & Syntactic and semantic checks.
+ Fig.~\ref{figure:namecheck} $^*$ \\
+ Syntax Checker & Syntactic checks only. $^*$ \\
+ Position Converter & Convert chromosomal positions to gene-centered
+ notation (no semantic check)
+ Fig.~\ref{figure:positionconvert} $^*$ \\
+ SNP Converter & Convert a dbSNP rsId to HGVS notation. $^*$ \\
+ Name Generator & Contruct a HGVS notation. \\
+ GenBank Uploader & Upload custom GenBank files. \\
+ Webservices & Programmatic (SOAP) interface. \\
+ \end{tabular}
+
+ $^*$ Also available as a batch interface.
+ }
+ \colorBlock{Background}{References}{1}{
+ {\small
+ \bibliography{$HOME/projects/bibliography}{}
+ }
+ }
+ \end{myPoster}
+\end{frame}
+\end{document}
diff --git a/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/ul_logo.eps b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/ul_logo.eps
new file mode 120000
index 0000000000000000000000000000000000000000..34ff36adfdd3334d097d7f00218acd90c7beac5d
--- /dev/null
+++ b/doc/Poster_19_20-04-11_NBIC_Mutalyzer2/ul_logo.eps
@@ -0,0 +1 @@
+/local/projects/poster/trunk/ul_logo.eps
\ No newline at end of file
diff --git a/doc/Presentation_24-02-11_HumGen_Mutalyzer2/picture.tex b/doc/Presentation_24-02-11_HumGen_Mutalyzer2/picture.tex
new file mode 100644
index 0000000000000000000000000000000000000000..2a8887fb45b8a395874ba8636ad9a94b0a6152f7
--- /dev/null
+++ b/doc/Presentation_24-02-11_HumGen_Mutalyzer2/picture.tex
@@ -0,0 +1,40 @@
+\providecommand{\positionpicture}{
+ \vspace{-0.5cm}
+ \begin{center}
+ \fbox{
+ \begin{picture}(300, 60)(0, 0)
+ \put(0, 30){\line(1, 0){300}} % Genomic sequence.
+ \linethickness{4pt}
+ \put(50, 30){\line(1, 0){30}} % Non-coding parts of the exons.
+ \put(220, 30){\line(1, 0){10}}
+ \linethickness{12pt}
+ \put(80, 30){\line(1, 0){20}} % Coding parts of the exons.
+ \put(150, 30){\line(1, 0){20}}
+ \put(200, 30){\line(1, 0){20}}
+
+ \linethickness{0.5pt}
+ \put(20, 50){\scriptsize{Transcription start}}
+ \put(50, 45){\vector(0, -1){10}}
+ \put(200, 50){\scriptsize{Transcription end}}
+ \put(230, 45){\vector(0, -1){10}}
+
+ \put(70, 0){\scriptsize{CDS start}}
+ \put(80, 10){\vector(0, 1){10}}
+ \put(210, 0){\scriptsize{CDS stop}}
+ \put(220, 10){\vector(0, 1){10}}
+
+ \put(0, 0){\scriptsize{Genomic end}}
+ \put(0, 10){\vector(0, 1){10}}
+ \put(255, 0){\scriptsize{Genomic start}}
+ \put(300, 10){\vector(0, 1){10}}
+
+ \put(95, 50){\color{yellow}\scriptsize{Variant A}\color{white}}
+ \put(115, 45){\color{yellow}\vector(0, -1){10}\color{white}}
+
+ \put(140, 50){\color{yellow}\scriptsize{Variant B}\color{white}}
+ \put(160, 45){\color{yellow}\vector(0, -1){10}\color{white}}
+ \end{picture}
+ }
+ \end{center}
+ \bigskip
+}