diff --git a/requirements.txt b/requirements.txt
index 75bbd5820b0c54a107839a898b33882bfd71182c..250f4ff139bdd182f2e46a2688709b7c91db59c7 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,29 +1,29 @@
 -e git+https://github.com/LUMC/magic-python.git#egg=Magic_file_extensions
 Flask==0.10.1
-Jinja2==2.7.3
+Jinja2==2.8
 MySQL-python==1.2.5
 PyYAML==3.11
-SQLAlchemy==0.9.8
-Sphinx==1.2.3
-Werkzeug==0.9.6
+SQLAlchemy==1.0.9
+Sphinx==1.3.1
+Werkzeug==0.10.4
 alembic==0.8.3
 backtranslate==0.0.5
-biopython==1.64
+biopython==1.66
 chardet==2.3.0
 cssselect==0.9.1
 description-extractor==2.2.1
 interval-binning==1.0.0
-lxml==3.4.0
-mock==1.0.1
-mockredispy==2.9.0.9
-pyparsing==2.0.3
+lxml==3.4.4
+mock==1.3.0
+mockredispy==2.9.0.11
+pyparsing==2.0.5
 pytest==2.8.2
-pytz==2014.7
-redis==2.10.3
-requests==2.4.3
-simplejson==3.6.4
-sphinx-rtd-theme==0.1.6
-spyne==2.11.0
+pytz==2015.7
+redis==2.10.5
+requests==2.8.1
+simplejson==3.8.1
+sphinx-rtd-theme==0.1.9
+spyne==2.12.11
 suds==0.4
 wsgiref==0.1.2
-xlrd==0.9.3
+xlrd==0.9.4