At this moment the following variant callers can be used
##### Germline
When doing variantcalling mostly germline is used. This will detect variants based on the assumption that there is a fixed number of alleles. Mostly the default used is a ploidy of 2. When this assumption does not hold for your data somatic variantcalling can be a better solution.
In contrast to germline variantcalling does somatic variantcalling does not have a direct assumption about the number of alleles. Some can also take a control into account, like MuTect2. Having a control is useful when analysing tumor samples.