diff --git a/notebook.ipynb b/notebook.ipynb
index ff7d920b6194c5f05814f776b048a798f34b4037..0cb4c87d901ec0f1b37b591f5fbb38db72be2574 100644
--- a/notebook.ipynb
+++ b/notebook.ipynb
@@ -1,7 +1,7 @@
 {
  "metadata": {
   "name": "",
-  "signature": "sha256:f32a4926b7461da7133e01bae5a7f9c6b580667534ff6f2af9832df26de9c88e"
+  "signature": "sha256:50f0011df38c64a61f87d0fd5e0bd41496c221072c1ed80168340a42e699384e"
  },
  "nbformat": 3,
  "nbformat_minor": 0,
@@ -88,15 +88,14 @@
      "level": 4,
      "metadata": {},
      "source": [
-      "The cornerstones of the scientific method:"
+      "The cornerstone of the scientific method:"
      ]
     },
     {
      "cell_type": "markdown",
      "metadata": {},
      "source": [
-      "- Replication\n",
-      "- Reproduction"
+      "- Replication & Reproduction"
      ]
     },
     {
@@ -181,7 +180,15 @@
      "level": 4,
      "metadata": {},
      "source": [
-      "Strong position!"
+      "Lots of reasons to python!\n"
+     ]
+    },
+    {
+     "cell_type": "heading",
+     "level": 4,
+     "metadata": {},
+     "source": [
+      "How to python?"
      ]
     },
     {
@@ -271,7 +278,7 @@
      "source": [
       "- Started by typing 'ipython notebook' in the directory where you want to store notebooks\n",
       "- Opens a new browser window with an index page where existing notebooks are shown\n",
-      "- New notebooks can be created in that directory"
+      "- New notebooks can be created in that same directory"
      ]
     },
     {
@@ -364,11 +371,12 @@
      "metadata": {},
      "source": [
       "- Install locally\n",
-      "    - See instructions in this course\n",
+      "  - See instructions in this course\n",
+      "  - Linux, Windows\n",
       "    \n",
       "    \n",
-      "- Shark cluster LUMC\n",
-      "    - Type 'notebook' and click the URL"
+      "- Remotely, Shark cluster LUMC\n",
+      "  - Type 'notebook' and click the given URL"
      ]
     },
     {
@@ -418,7 +426,7 @@
       "    - Indicated with a <font color='grey'>grey</font> cell border\n",
       "    - Edit the notebook as a whole\n",
       "\n",
-      "Different shortcuts apply in both modes!\n",
+      "Note: Different shortcuts apply in both modes!\n",
       "\n",
       "\n"
      ]
@@ -434,13 +442,10 @@
     {
      "cell_type": "code",
      "collapsed": false,
-     "input": [
-      "a = 12"
-     ],
+     "input": [],
      "language": "python",
      "metadata": {},
-     "outputs": [],
-     "prompt_number": 63
+     "outputs": []
     },
     {
      "cell_type": "heading",
@@ -472,7 +477,6 @@
       "\n",
       "\n",
       "- esc : command mode\n",
-      "- ctrl+m : command mode\n",
       "- shift+enter : run cell\n",
       "- ctrl+enter : run cell, select below\n"
      ]
@@ -492,19 +496,61 @@
       "- enter : edit mode\n",
       "- shift+enter : run cell\n",
       "- ctrl+enter : run cell, select below\n",
+      "\n",
+      "\n",
       "- y : to code\n",
       "- m : to markdown\n",
+      "\n",
+      "\n",
       "- ctrl+k : move cell up\n",
       "- ctrl+j : move cell down\n",
+      "\n",
+      "\n",
       "- a : insert cell above\n",
       "- b : insert cell below\n",
+      "\n",
+      "\n",
       "- x : cut cell\n",
       "- c : copy cell\n",
       "- v : paste cell below\n",
+      "\n",
+      "\n",
       "- z : undo last delete\n",
       "- d : delete cell (press twice)"
      ]
     },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
+     "source": [
+      "Press 'h' to show the help."
+     ]
+    },
+    {
+     "cell_type": "heading",
+     "level": 1,
+     "metadata": {},
+     "source": [
+      "Saving your notebook\n"
+     ]
+    },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
+     "source": [
+      "- The notebook automatically saves\n",
+      "- You can manually click the 'save' icon or press CTRL+s"
+     ]
+    },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
+     "source": [
+      "**Checkpoints**\n",
+      "\n",
+      "Currently only single checkpoints are stored, but multiple checkpoints will be enabled for future versions of IPython and Bookstore. "
+     ]
+    },
     {
      "cell_type": "heading",
      "level": 1,
@@ -539,8 +585,7 @@
      "cell_type": "markdown",
      "metadata": {},
      "source": [
-      "- Markdown cell\n",
-      "    - Format your document nicely\n"
+      "This is a markdown cell which allows to format your document nicely and add context to code cells."
      ]
     },
     {
@@ -564,13 +609,29 @@
      "level": 1,
      "metadata": {},
      "source": [
-      "Running code in a code cell"
+      "Running python code"
      ]
     },
     {
      "cell_type": "heading",
      "level": 4,
      "metadata": {},
+     "source": [
+      "All of the python goodness works!"
+     ]
+    },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
+     "source": [
+      "- Cells run asynchronous\n",
+      "- Results are persistent\n",
+      "- Save time by running intensive code blocks only once"
+     ]
+    },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
      "source": [
       "Run a code cell by pressing the play button or shift+enter"
      ]
@@ -595,69 +656,23 @@
        ]
       }
      ],
-     "prompt_number": 43
+     "prompt_number": 10
     },
     {
-     "cell_type": "heading",
-     "level": 1,
+     "cell_type": "markdown",
      "metadata": {},
      "source": [
-      "\u00a7 Excercise : My first Notebook"
+      "Use the 'Cell' option in the toolbar to run multiple cells at once."
      ]
     },
     {
      "cell_type": "markdown",
      "metadata": {},
      "source": [
-      "Start a Notebook session.\n",
-      "    - $ ipython notebook\n",
-      "This opens a webbrowser and shows existing notebooks.\n",
-      "    - Create a new notebook by clicking the 'New notebook' button.\n",
-      "A new tab will open with a fresh notebook. Rename your notebook to something useful\n",
-      "    - Click on the current name (Untitled1) and edit this\n",
-      "Add the code shown below to some cells\n",
-      "    - Add cells by pressen the '+' button or ALT+ENTER"
+      "- If the kernel is busy running it states 'Busy' in the header of the window or tab\n",
+      "- The indicator in the top right corner shows the kernel state"
      ]
     },
-    {
-     "cell_type": "code",
-     "collapsed": false,
-     "input": [
-      "complements = {'A': 'T', 'C': 'G', 'T': 'A', 'G': 'C'} "
-     ],
-     "language": "python",
-     "metadata": {},
-     "outputs": [],
-     "prompt_number": 1
-    },
-    {
-     "cell_type": "code",
-     "collapsed": false,
-     "input": [
-      "def translate(s):\n",
-      "    c  = ''\n",
-      "    for i in s:\n",
-      "        c  = c + complements[i]\n",
-      "    return c"
-     ],
-     "language": "python",
-     "metadata": {},
-     "outputs": [],
-     "prompt_number": 3
-    },
-    {
-     "cell_type": "code",
-     "collapsed": false,
-     "input": [
-      "def reverse(s):\n",
-      "    rev = s[::-1]\n",
-      "    return rev"
-     ],
-     "language": "python",
-     "metadata": {},
-     "outputs": [],
-     "prompt_number": 7
-    },
     {
      "cell_type": "heading",
      "level": 1,
@@ -801,37 +816,65 @@
     },
     {
      "cell_type": "heading",
-     "level": 4,
+     "level": 1,
      "metadata": {},
      "source": [
-      "Exceptions are formatted nicely:"
+      "\u00a7 Excercise : My first Notebook"
+     ]
+    },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
+     "source": [
+      "Start a Notebook session.\n",
+      "  - $ ipython notebook\n",
+      "This opens a webbrowser and shows existing notebooks.\n",
+      "  - Create a new notebook by clicking the 'New notebook' button.\n",
+      "A new tab will open with a fresh notebook. Rename your notebook to something useful\n",
+      "  - Click on the current name (Untitled1) and edit this\n",
+      "Add the code shown below to some **_code_** cells\n",
+      "  - Add cells by pressen the '+' button or ALT+ENTER\n",
+      "  - Remember the keyboard shortcuts or the help function ('h')\n",
+      "\n",
+      "\n",
+      "Notice the laste cell produced output! We will continue to develop this notebook later this session."
      ]
     },
     {
      "cell_type": "code",
      "collapsed": false,
      "input": [
-      "# Let's distribute a few cookies to nobody\n",
-      "cookies = 3\n",
-      "persons = 0\n",
-      "share = cookies / persons\n",
-      "print share"
+      "def translate(seq):\n",
+      "    complements = {'A': 'T', 'C': 'G', 'T': 'A', 'G': 'C'}\n",
+      "    c_seq  = ''\n",
+      "    for n in seq:\n",
+      "        c_seq  = c_seq + complements[n]\n",
+      "    return c_seq"
+     ],
+     "language": "python",
+     "metadata": {},
+     "outputs": [],
+     "prompt_number": 40
+    },
+    {
+     "cell_type": "code",
+     "collapsed": false,
+     "input": [
+      "translate('ACGT')"
      ],
      "language": "python",
      "metadata": {},
      "outputs": [
       {
-       "ename": "ZeroDivisionError",
-       "evalue": "integer division or modulo by zero",
-       "output_type": "pyerr",
-       "traceback": [
-        "\u001b[1;31m---------------------------------------------------------------------------\u001b[0m\n\u001b[1;31mZeroDivisionError\u001b[0m                         Traceback (most recent call last)",
-        "\u001b[1;32m<ipython-input-51-0d805d7db48f>\u001b[0m in \u001b[0;36m<module>\u001b[1;34m()\u001b[0m\n\u001b[0;32m      2\u001b[0m \u001b[0mcookies\u001b[0m \u001b[1;33m=\u001b[0m \u001b[1;36m3\u001b[0m\u001b[1;33m\u001b[0m\u001b[0m\n\u001b[0;32m      3\u001b[0m \u001b[0mpersons\u001b[0m \u001b[1;33m=\u001b[0m \u001b[1;36m0\u001b[0m\u001b[1;33m\u001b[0m\u001b[0m\n\u001b[1;32m----> 4\u001b[1;33m \u001b[0mshare\u001b[0m \u001b[1;33m=\u001b[0m \u001b[0mcookies\u001b[0m \u001b[1;33m/\u001b[0m \u001b[0mpersons\u001b[0m\u001b[1;33m\u001b[0m\u001b[0m\n\u001b[0m\u001b[0;32m      5\u001b[0m \u001b[1;32mprint\u001b[0m \u001b[0mshare\u001b[0m\u001b[1;33m\u001b[0m\u001b[0m\n",
-        "\u001b[1;31mZeroDivisionError\u001b[0m: integer division or modulo by zero"
+       "metadata": {},
+       "output_type": "pyout",
+       "prompt_number": 41,
+       "text": [
+        "'TGCA'"
        ]
       }
      ],
-     "prompt_number": 51
+     "prompt_number": 41
     },
     {
      "cell_type": "heading",
@@ -848,7 +891,7 @@
       "- When a cell is run it can generate output\n",
       "- This is shown below the cell in the output area\n",
       "- Output is asynchronous\n",
-      "- Outputs are objects and are available under the variable '_'\n",
+      "- Outputs are objects and the last one is available under the variable '_'\n",
       "    "
      ]
     },
@@ -929,6 +972,40 @@
      ],
      "prompt_number": 115
     },
+    {
+     "cell_type": "heading",
+     "level": 4,
+     "metadata": {},
+     "source": [
+      "Exceptions are formatted nicely:"
+     ]
+    },
+    {
+     "cell_type": "code",
+     "collapsed": false,
+     "input": [
+      "# Let's distribute a few cookies to nobody\n",
+      "cookies = 3\n",
+      "persons = 0\n",
+      "share = cookies / persons\n",
+      "print share"
+     ],
+     "language": "python",
+     "metadata": {},
+     "outputs": [
+      {
+       "ename": "ZeroDivisionError",
+       "evalue": "integer division or modulo by zero",
+       "output_type": "pyerr",
+       "traceback": [
+        "\u001b[1;31m---------------------------------------------------------------------------\u001b[0m\n\u001b[1;31mZeroDivisionError\u001b[0m                         Traceback (most recent call last)",
+        "\u001b[1;32m<ipython-input-51-0d805d7db48f>\u001b[0m in \u001b[0;36m<module>\u001b[1;34m()\u001b[0m\n\u001b[0;32m      2\u001b[0m \u001b[0mcookies\u001b[0m \u001b[1;33m=\u001b[0m \u001b[1;36m3\u001b[0m\u001b[1;33m\u001b[0m\u001b[0m\n\u001b[0;32m      3\u001b[0m \u001b[0mpersons\u001b[0m \u001b[1;33m=\u001b[0m \u001b[1;36m0\u001b[0m\u001b[1;33m\u001b[0m\u001b[0m\n\u001b[1;32m----> 4\u001b[1;33m \u001b[0mshare\u001b[0m \u001b[1;33m=\u001b[0m \u001b[0mcookies\u001b[0m \u001b[1;33m/\u001b[0m \u001b[0mpersons\u001b[0m\u001b[1;33m\u001b[0m\u001b[0m\n\u001b[0m\u001b[0;32m      5\u001b[0m \u001b[1;32mprint\u001b[0m \u001b[0mshare\u001b[0m\u001b[1;33m\u001b[0m\u001b[0m\n",
+        "\u001b[1;31mZeroDivisionError\u001b[0m: integer division or modulo by zero"
+       ]
+      }
+     ],
+     "prompt_number": 51
+    },
     {
      "cell_type": "heading",
      "level": 1,
@@ -941,7 +1018,7 @@
      "cell_type": "markdown",
      "metadata": {},
      "source": [
-      "Formatted **text** _can_ **_be_** ~~aded~~ added to IPython Notebooks using Markdown cells. \n",
+      "Formatted **text** _can_ **_be_** added to IPython Notebooks using Markdown cells. \n",
       "\n"
      ]
     },
@@ -961,6 +1038,17 @@
       "http://daringfireball.net/projects/markdown/"
      ]
     },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
+     "source": [
+      "To create a markdown cell:\n",
+      "- First focus on the cell you want to format\n",
+      "- Then select 'Markdown' the dropdown box in the toolbar or press 'm' in command mode\n",
+      "- Note that you need to run a markdown cell to show the result\n",
+      "    - Click 'play' or SHIFT+ENTER"
+     ]
+    },
     {
      "cell_type": "heading",
      "level": 1,
@@ -1037,6 +1125,13 @@
       "General HTML"
      ]
     },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
+     "source": [
+      "Since markdown is a subset of HTML, this will also work"
+     ]
+    },
     {
      "cell_type": "raw",
      "metadata": {},
@@ -1081,6 +1176,13 @@
       "Markdown also supports formulas"
      ]
     },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
+     "source": [
+      "Nicely formatted"
+     ]
+    },
     {
      "cell_type": "raw",
      "metadata": {},
@@ -1097,77 +1199,83 @@
     },
     {
      "cell_type": "heading",
-     "level": 1,
+     "level": 4,
      "metadata": {},
      "source": [
-      "\u00a7 Excercise : My next Notebook"
+      "We can also show figures. These can be locally or linked from the www."
      ]
     },
     {
      "cell_type": "markdown",
      "metadata": {},
      "source": [
-      "Let's add some markdown cells\n",
-      "- Select the top code cell, press ESC to go into command mode\n",
-      "- Press 'b', this will add a cell above the selected cell\n",
-      "- Notice the focus is on the new cell\n",
-      "- Now press 'm' to set the celltype to Markdown\n",
-      "- Press ENTER and add some text"
+      "- Notebook has acceess to all the files down in the directory"
      ]
     },
     {
      "cell_type": "markdown",
      "metadata": {},
      "source": [
-      "### My next notebook\n",
-      "[Michiel van Galen](mailto:m.van_galen@lumc.nl)"
+      "![LUMC](https://www.lumc.nl/images/html5/logo-lumc.png)"
      ]
     },
     {
-     "cell_type": "code",
-     "collapsed": false,
-     "input": [
-      "complements = {'A': 'T', 'C': 'G', 'T': 'A', 'G': 'C'} "
-     ],
-     "language": "python",
+     "cell_type": "markdown",
      "metadata": {},
-     "outputs": [],
-     "prompt_number": 8
+     "source": [
+      "![LUMC](https://www.lumc.nl/images/html5/logo-lumc.png)"
+     ]
     },
     {
-     "cell_type": "code",
-     "collapsed": false,
-     "input": [
-      "def translate(s):\n",
-      "    c  = ''\n",
-      "    for i in s:\n",
-      "        c  = c + complements[i]\n",
-      "    return c"
-     ],
-     "language": "python",
+     "cell_type": "heading",
+     "level": 1,
      "metadata": {},
-     "outputs": [],
-     "prompt_number": 9
+     "source": [
+      "<br></br><br></br>\n",
+      "Some final examples:"
+     ]
     },
     {
-     "cell_type": "code",
-     "collapsed": false,
-     "input": [
-      "def reverse(s):\n",
-      "    rev = s[::-1]\n",
-      "    return rev"
-     ],
-     "language": "python",
+     "cell_type": "heading",
+     "level": 4,
      "metadata": {},
-     "outputs": []
+     "source": [
+      "Python supports videos also. Note this is not a markdown cell, but a code cell using a python package."
+     ]
     },
     {
      "cell_type": "code",
      "collapsed": false,
-     "input": [],
+     "input": [
+      "from IPython.display import YouTubeVideo\n",
+      "# a talk about IPython at Sage Days at U. Washington, Seattle.\n",
+      "# Video credit: William Stein.\n",
+      "YouTubeVideo('1j_HxD4iLn8')"
+     ],
      "language": "python",
      "metadata": {},
-     "outputs": []
+     "outputs": [
+      {
+       "html": [
+        "\n",
+        "        <iframe\n",
+        "            width=\"400\"\n",
+        "            height=300\"\n",
+        "            src=\"https://www.youtube.com/embed/1j_HxD4iLn8\"\n",
+        "            frameborder=\"0\"\n",
+        "            allowfullscreen\n",
+        "        ></iframe>\n",
+        "        "
+       ],
+       "metadata": {},
+       "output_type": "pyout",
+       "prompt_number": 34,
+       "text": [
+        "<IPython.lib.display.YouTubeVideo at 0x331c850>"
+       ]
+      }
+     ],
+     "prompt_number": 34
     },
     {
      "cell_type": "heading",
@@ -1178,11 +1286,10 @@
      ]
     },
     {
-     "cell_type": "heading",
-     "level": 4,
+     "cell_type": "markdown",
      "metadata": {},
      "source": [
-      "More on this later in the course"
+      "More on this later in the course."
      ]
     },
     {
@@ -1202,93 +1309,139 @@
        "output_type": "display_data",
        "png": 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lBr9SzUFEfhEMwj/+YVNizJljHdDiT0oOIgJAdrb1K6xZAwsWQKVKbkckblKzkoiwZw+0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\nRK5CYII=\n",
        "text": [
-        "<matplotlib.figure.Figure at 0x3cda910>"
+        "<matplotlib.figure.Figure at 0x333b590>"
        ]
       }
      ],
-     "prompt_number": 21
+     "prompt_number": 36
     },
     {
      "cell_type": "heading",
-     "level": 4,
+     "level": 1,
      "metadata": {},
      "source": [
-      "Support for Latex"
+      "\u00a7 Excercise : My first Notebook"
+     ]
+    },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
+     "source": [
+      "Let's add some markdown cells to the notebook you created earlier:\n",
+      "  - Select the top code cell\n",
+      "  - Press ESC to go into command mode\n",
+      "  - Press 'b', this will add a cell above the selected cell\n",
+      "  - Notice the focus is on the new cell\n",
+      "  - Now press 'm' to set the celltype to Markdown\n",
+      "  - Press ENTER and add some code (see below for example)\n",
+      "  - Run the cell and see if it worked\n"
+     ]
+    },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
+     "source": [
+      "Example markdown code:"
+     ]
+    },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
+     "source": [
+      "### My next notebook\n",
+      "\n",
+      "This notebook is my first notebook with some experimental code.\n",
+      "\n",
+      "Author: [Michiel van Galen](mailto:m.van_galen@lumc.nl)"
+     ]
+    },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
+     "source": [
+      "Now, try to add more python code to the notebook:\n",
+      " - Make sure to set the cell type to code\n",
+      " - Add the 'reverse' function to your notebook as shown below"
      ]
     },
     {
      "cell_type": "code",
      "collapsed": false,
      "input": [
-      "from IPython.display import Math\n",
-      "Math(r'F(k) = \\int_{-\\infty}^{\\infty} f(x) e^{2\\pi i k} dx')\n"
+      "def reverse(seq):\n",
+      "    rev = seq[::-1]\n",
+      "    return rev"
      ],
      "language": "python",
      "metadata": {},
-     "outputs": [
-      {
-       "latex": [
-        "$$F(k) = \\int_{-\\infty}^{\\infty} f(x) e^{2\\pi i k} dx$$"
-       ],
-       "metadata": {},
-       "output_type": "pyout",
-       "prompt_number": 126,
-       "text": [
-        "<IPython.core.display.Math at 0x3318ed0>"
-       ]
-      }
-     ],
-     "prompt_number": 126
+     "outputs": [],
+     "prompt_number": 42
     },
     {
-     "cell_type": "heading",
-     "level": 1,
+     "cell_type": "markdown",
      "metadata": {},
      "source": [
-      "Other integration such as videos"
+      "Try using both the 'reverse' and 'translate' function."
      ]
     },
     {
-     "cell_type": "heading",
-     "level": 4,
+     "cell_type": "code",
+     "collapsed": false,
+     "input": [
+      "reverse('AACGT')"
+     ],
+     "language": "python",
      "metadata": {},
-     "source": [
-      "For example youtube"
-     ]
+     "outputs": [
+      {
+       "metadata": {},
+       "output_type": "pyout",
+       "prompt_number": 45,
+       "text": [
+        "'TGCAA'"
+       ]
+      }
+     ],
+     "prompt_number": 45
     },
     {
      "cell_type": "code",
      "collapsed": false,
      "input": [
-      "from IPython.display import YouTubeVideo\n",
-      "# a talk about IPython at Sage Days at U. Washington, Seattle.\n",
-      "# Video credit: William Stein.\n",
-      "YouTubeVideo('1j_HxD4iLn8')"
+      "translate(_)"
      ],
      "language": "python",
      "metadata": {},
      "outputs": [
       {
-       "html": [
-        "\n",
-        "        <iframe\n",
-        "            width=\"400\"\n",
-        "            height=300\"\n",
-        "            src=\"https://www.youtube.com/embed/1j_HxD4iLn8\"\n",
-        "            frameborder=\"0\"\n",
-        "            allowfullscreen\n",
-        "        ></iframe>\n",
-        "        "
-       ],
        "metadata": {},
        "output_type": "pyout",
-       "prompt_number": 116,
+       "prompt_number": 46,
        "text": [
-        "<IPython.lib.display.YouTubeVideo at 0x331a6d0>"
+        "'ACGTT'"
        ]
       }
      ],
-     "prompt_number": 116
+     "prompt_number": 46
+    },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
+     "source": [
+      "Palindromic sequences play an important role in molecular biology:\n",
+      "\n",
+      "http://en.wikipedia.org/wiki/Palindromic_sequence"
+     ]
+    },
+    {
+     "cell_type": "markdown",
+     "metadata": {},
+     "source": [
+      "Add the following features to your notebook:\n",
+      " - Think of function which can test if a seqeunce is palindromic\n",
+      " - Nicely formatted mardown cell(s) explaining the notebook\n",
+      "   - Add links as references like above"
+     ]
     },
     {
      "cell_type": "heading",
@@ -1299,6 +1452,7 @@
       "<br></br><br></br><br></br><br></br>\n",
       "<br></br><br></br><br></br><br></br>\n",
       "<br></br><br></br><br></br><br></br>\n",
+      "<br></br><br></br><br></br><br></br>\n",
       "Ignore following code for layout"
      ]
     },