version 1.0 import "common.wdl" as common task ConfigureGermline { input { String? preCommand String? installDir String runDir Array[File]+ bams Array[File]+ indexes Reference reference File? callRegions File? callRegionsIndex Boolean exome = false Boolean rna = false } String toolCommand = if defined(installDir) then installDir + "bin/configureStrelkaGermlineWorkflow.py" else "configureStrelkaGermlineWorkflow.py" command { set -e -o pipefail ~{preCommand} ~{toolCommand} \ --bam ~{sep=" --bam " bams} \ --ref ~{reference.fasta} \ --runDir ~{runDir} \ ~{"--callRegions " + callRegions} \ ~{true="--exome" false="" exome} \ ~{true="--rna" false="" rna} } output { String runDirectory = runDir } } task ConfigureSomatic { input { String? preCommand String? installDir String runDir IndexedBamFile normalBam IndexedBamFile tumorBam Reference reference File? callRegions File? callRegionsIndex IndexedVcfFile? indelCandidates Boolean exome = false } String toolCommand = if defined(installDir) then installDir + "bin/configureStrelkaSomaticWorkflow.py" else "configureStrelkaSomaticWorkflow.py" String indelCandidatesArg = if (defined(indelCandidates)) then "--indelCandidates " + select_first([indelCandidates]).file else "" command { set -e -o pipefail ~{preCommand} ~{toolCommand} \ --normalBam ~{normalBam.file} \ --tumorBam ~{tumorBam.file} \ --ref ~{reference.fasta} \ --runDir ~{runDir} \ ~{"--callRegions " + callRegions} \ ~{indelCandidatesArg} \ ~{true="--exome" false="" exome} \ } output { String runDirectory = runDir } } task Run { input { String runDir Int cores = 1 Int memory = 4 Boolean somatic = true #FIXME: This task does not have input files } command { ~{runDir}/runWorkflow.py \ -m local \ -j ~{cores} \ -g ~{memory} } output { File? indelsVcf = runDir + "/results/variants/somatic.indels.vcf.gz" File? indelsIndex = runDir + "/results/variants/somatic.indels.vcf.gz.tbi" File variants = if somatic then runDir + "/results/variants/somatic.snvs.vcf.gz" else runDir + "/results/variants/variants.vcf.gz" File variantsIndex = if somatic then runDir + "/results/variants/somatic.snvs.vcf.gz.tbi" else runDir + "/results/variants/variants.vcf.gz.tbi" } runtime { cpu: cores memory: memory } }